Dr John Foster
Working with cells and molecules to find new treatments for diseases
Research
Research
Molecular Biology
- Passionate molecular biologist with expertise in RNA biology and in vitro transcription of mRNA vaccines.
- Skilled in various molecular techniques such as PCR, gel electrophoresis, DNA and RNA sequencing, and cloning.
- Experienced in lentivirus and CRISPR-Cas9 gene editing for precise control and manipulation of gene expression.
- Empowered to study the impact of gene expression on diverse biological processes.
Cell Biology
- Experienced in cell biology with a focus on primary human cells and pre-clinical cancer models.
- Proficient in isolating and cultivating primary human cells while preserving their unique characteristics and functions.
- Skilled in working with primary air liquid interface models of lung cancer for more accurate pre-clinical research.
- Expertise in modeling cellular stresses such as hypoxia and inflammation to analyze resultant changes in cellular behavior.
Clinical Research
- Diverse career in biomedical research with expertise in managing clinical trial samples.
- Conducted research on biomarkers of prostate cancer using omics data and advanced statistical modeling.
- Understanding of data analysis techniques, including machine learning algorithms, for the development of effective biomarkers.
- Currently working for a discovery stage biotech startup focused on creating cross-protective vaccines, driven by a passion for scientific discovery and meaningful impact in biomedicine.
Computational Biology
- Keen interest in multiomics data analysis, including DNA and RNA sequencing, RNA splicing analysis, and proteomics.
- Currently learning R and Python programming languages for data analysis, automation of repetitive tasks, and custom pipeline development.
- Growing interest in machine learning techniques and their application to biological data to reveal patterns and relationships in complex biological systems.
- Excited about the potential of multiomics data analysis and machine learning in the field of molecular biology and eager to explore innovative ways to analyze biological data.
Papers
Papers
HNRNPA2B1 controls an unfolded protein response-related prognostic gene signature in prostate cancer
Foster JG, Gea EEM, Labiba MA, Anene CA, Stockley J, Philippe C, Cereda M, Rouault-Pierre K, Leung HY, Bessant C, Rajan P BioRXiv pre-print 2022
FOXA1 regulates alternative splicing in prostate cancer
Foster JG*, Del Giudice M*, Peirone S, Rissone A, Caizzi L, Gaudino F, Parlato C, Anselmi F, Arkell R, Guarrera S, Oliviero S, Basso G, Rajan P*, Cereda M* Cell Reports 2022 Sep 27;40(13):111404.
A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang TY, Shaw PE, Reynolds LE, McKay TR, Wang HW, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I, Sharp TV. EMBO Molelcular Medicine 2018 Aug;10(8).
Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG, Rose R, Hodgkinson MR, Ribeiro PS, Aboobaker AA, Yashiro K, Wang X, Graves PR, Plevin MJ, Lagos D, Sharp TV. Cell Reports 2017 Jul 5;20(1):173-187.
Foster JG, Carter E, Kilty I, Mackenzie AB, Ward SG. Journal of Immunology 2013 Feb 15;190(4):1551-9.
Foster JG, Blunt MD, Carter E, Ward SG. Pharmacol Rev. 2012 Oct;64(4):1027-54